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研究发现关节炎治疗药物可促进脂肪信号传递 并能对抗肥胖小鼠的糖尿病_我的网站

A |     The Indian External Affairs Ministry on Wednesday slammed the United Nations’ Office of the High Commissioner for Human Rights (UN OHCHR) for making remarks on the arrest of activist Teesta Setalvad and two others.,The ministry's official spokesperson Arindam Bagchi said in a statement: "We have seen a comment by the Office of the High Commissioner for Human Rights regarding legal action against Teesta Setalvad and two other persons.”,Describing the remarks as “unwarranted”, the spokesperson said: “Authorities in India act against violations of law strictly in accordance with established judicial processes. Labelling such legal actions as persecution for activism is misleading and unacceptable.”,He also said that such remarks “constitute an interference in India’s independent judicial system.”,Earlier this week, the UN’s OHCHR had voiced concern over the arrest and detention of social activist Setalvad and two former police officials, while calling for their immediate release.,Setalvad and former police officials Sreekumar, and Sanjiv Bhatt, were arrested by Gujarat Police last week after a police complaint was filed in Ahmedabad city by a police official, Darshansinh B. Barad.,They are being accused of conspiring to fabricate facts and documents, tutoring witnesses, and abusing the process of law by fabricating false evidence to frame people, based on the submissions made before the Special Investigation Team (SIT) formed by the Indian Supreme Court to investigate the 2002 Gujarat Riots.,The arrests came a day after India’s apex court dismissed the petition filed by Setalvad and Zakia Jafri, widow of Congress parliamentarian Ehsan Jafri, in connection to 2002 riots, and gave clean chit to the then State Chief of Gujarat Narendra Modi and others.,Ehsan Jafri was killed during the riots which had erupted in Gujarat after a train carrying Hindu pilgrims returning from Ayodhya was set ablaze.。    在贝勒医学院研究人员的领导下，这项研究源于围绕炎症在胰岛素抵抗中所扮演的角色的新兴知识，以及如何将控制炎症的药物用于对抗糖尿病。作为糖尿病的一个特征，胰岛素抵抗是指细胞无法对激素做出反应并从血液中吸收葡萄糖，而研究已经在它和白色脂肪组织的炎症之间建立了联系。为了更好地了解这些关联，该研究的作者在现有的药物数据库中进行筛选，寻找一种可能同时影响炎症和糖尿病的药物。第一作者和共同通讯作者Aaron R. Cox博士说：“我们通过计算筛选了一个小分子数据集，并确定了auranofin，这是一种美国食品和药物管理局批准的药物，已被用于治疗类风湿性关节炎，一种涉及炎症的疾病。Auranofin具有抗炎特性，许多人怀疑这对肥胖症和糖尿病有益；然而，对于它如何影响新陈代谢，人们并不了解。”科学家们用Auranofin治疗糖尿病小鼠模型，并仔细检查了代谢效果，让这些动物食用高脂肪饮食。其中一个关键的发现集中在一种叫做瘦素的激素上，这种激素由脂肪细胞产生，并向大脑发出信号，表明我们已经吃饱。

B | 在拥有更多脂肪细胞的肥胖受试者中，瘦素水平升高，打破了这些与大脑的沟通，导致他们通过所谓的瘦素抵抗而暴饮暴食。研究发现Auranofin能降低肥胖小鼠的瘦素水平。该药物还改善了白色脂肪组织的代谢信号，促进了更高的脂肪燃烧率，改善了胰岛素敏感性，并对抗了其他与肥胖有关的影响。然而，值得注意的是，它这样做并没有改变小鼠的身体组成。共同通讯作者Sean Hartig博士说：“我们发现Auranofin具有抗炎和抗糖尿病的作用，这些作用是相互独立的。Auranofin改善了胰岛素敏感性，或身体对胰岛素作出反应以保持血糖在健康水平的能力。

C | 该药物还使小鼠模型中与肥胖相关的变化正常化，如高胰岛素血症--血液中的胰岛素水平高于正常水平。此外，我们发现Auranofin在白色脂肪组织中的积累减少了炎症反应，而不改变肥胖小鼠的身体组成。”研究人员指出，在这些有希望的结果转化为临床治疗之前，还有很多工作要做，但对他们的早期发现充满热情。

D | 该研究发表在《细胞代谢》杂志上。

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